Xenotransplantation and exotransplantation: Strategies to expand the number of donor organs

Daniel J Garry; Joshua I Weiner; Sarah M Greising; David H Sachs; Mary G Garry

doi:10.1111/xen.12786

Xenotransplantation and exotransplantation: Strategies to expand the number of donor organs

Xenotransplantation. 2023 Jan;30(1):e12786. doi: 10.1111/xen.12786. Epub 2022 Nov 11.

Authors

Daniel J Garry^{1

2

3

4}, Joshua I Weiner⁵, Sarah M Greising⁶, David H Sachs^{5

7}, Mary G Garry^{1

2

3

4}

Affiliations

¹ Cardiovascular Division, Department of Medicine, University of Minnesota, Minneapolis, Minnesota, USA.
² Stem Cell Institute, University of Minnesota, Minneapolis, Minnesota, USA.
³ Lillehei Heart Institute, University of Minnesota, Minneapolis, Minnesota, USA.
⁴ NorthStar Genomics, Eagan, Minnesota, USA.
⁵ Department of Surgery, Columbia Center for Translational Immunology, Vagelos College of Physicians and Surgeons, Columbia University, New York, New York, USA.
⁶ School of Kinesiology, University of Minnesota, Minneapolis, Minnesota, USA.
⁷ Department of Surgery, Massachusetts General Hospital, Boston, Massachusetts, USA.

PMID: 36367201
DOI: 10.1111/xen.12786

Abstract

Cardiovascular disease is common and has a high mortality. Due to the limited number of organs available for orthotopic heart transplantation, alternative therapies have received intense interest. In this commentary we contrast xenotransplantation and blastocyst complementation to produce pigs that will serve as donors for organ transplantation. These strategies hold tremendous promise and have the potential to provide an unlimited number of organs for chronic, terminal diseases.

Keywords: ETV2; MYOD family; blastocyst complementation; skeletal muscle; xenotransplantation.

Publication types

Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Animals
Heart Transplantation*
Humans
Organ Transplantation*
Swine
Tissue Donors
Transplantation, Heterologous
Transplants*