Macrophages in health and disease

Cell. 2022 Nov 10;185(23):4259-4279. doi: 10.1016/j.cell.2022.10.007.


The heterogeneity of tissue macrophages, in health and in disease, has become increasingly transparent over the last decade. But with the plethora of data comes a natural need for organization and the design of a conceptual framework for how we can better understand the origins and functions of different macrophages. We propose that the ontogeny of a macrophage-beyond its fundamental derivation as either embryonically or bone marrow-derived, but rather inclusive of the course of its differentiation, amidst steady-state cues, disease-associated signals, and time-constitutes a critical piece of information about its contribution to homeostasis or the progression of disease.

Publication types

  • Review

MeSH terms

  • Bone Marrow*
  • Cell Differentiation
  • Homeostasis
  • Macrophages*