Dietary energy restriction in neurological diseases: what's new?

Eur J Nutr. 2023 Mar;62(2):573-588. doi: 10.1007/s00394-022-03036-1. Epub 2022 Nov 11.


Energy-restricted diet is a specific dietary regimen, including the continuous energy-restricted diet and the intermittent energy-restricted diet. It has been proven effective not only to reduce weight and extend the lifespan in animal models, but also to regulate the development and progression of various neurological diseases such as epilepsy, cerebrovascular diseases (stroke), neurodegenerative disorders (Alzheimer's disease and Parkinson's disease) and autoimmune diseases (multiple sclerosis). However, the mechanism in this field is still not clear and a systematic neurological summary is still missing. In this review, we first give a brief summary of the definition and mainstream strategies of energy restrictions. We then review evidence about the effects of energy-restricted diet from both animal models and human trials, and update the current understanding of mechanisms underlying the biological role of energy-restricted diet in the fight against neurological diseases. Our review thus contributes to the modification of dietary regimen and the search for special diet mimics.

Keywords: Dietary restriction; Epilepsy; Intermittent fasting; Ischemic stroke; Neurodegenerative disease; Special diet mimetic.

Publication types

  • Review

MeSH terms

  • Animals
  • Caloric Restriction*
  • Diet
  • Humans
  • Longevity
  • Stroke*