Targeted Therapies for Microvascular Disease

Interv Cardiol Clin. 2023 Jan;12(1):131-139. doi: 10.1016/j.iccl.2022.09.011.


Coronary microvascular dysfunction (CMD) is a common cause of ischemia but no obstructive coronary artery disease that results in an inability of the coronary microvasculature to meet myocardial oxygen demand. CMD is challenging to diagnose and manage due to a lack of mechanistic research and targeted therapy. Recent evidence suggests we can improved patient outcomes by stratifying antianginal therapies according to the diagnosis revealed by invasive assessment of the coronary microcirculation. This review article appraises the evidence for management of CMD, which includes treatment of cardiovascular risk, antianginal therapy and therapy for atherosclerosis.

Keywords: Angina; CMD; INOCA; Ischemia; Management.

Publication types

  • Review

MeSH terms

  • Coronary Artery Disease* / diagnosis
  • Coronary Circulation
  • Humans
  • Microcirculation
  • Myocardial Ischemia* / drug therapy