Development of γδ T cells in the thymus - A human perspective

Lena Boehme; Juliette Roels; Tom Taghon

doi:10.1016/j.smim.2022.101662

Development of γδ T cells in the thymus - A human perspective

Semin Immunol. 2022 Nov:61-64:101662. doi: 10.1016/j.smim.2022.101662. Epub 2022 Oct 29.

Authors

Lena Boehme¹, Juliette Roels¹, Tom Taghon²

Affiliations

¹ Department of Diagnostic Sciences, Ghent University, Ghent, Belgium.
² Department of Diagnostic Sciences, Ghent University, Ghent, Belgium; Cancer Research Institute Ghent (CRIG), Ghent, Belgium. Electronic address: tom.taghon@ugent.be.

PMID: 36374779
DOI: 10.1016/j.smim.2022.101662

Abstract

γδ T cells are increasingly emerging as crucial immune regulators that can take on innate and adaptive roles in the defence against pathogens. Although they arise within the thymus from the same hematopoietic precursors as conventional αβ T cells, the development of γδ T cells is less well understood. In this review, we focus on summarising the current state of knowledge about the cellular and molecular processes involved in the generation of γδ T cells in human.

Keywords: Human; Lineage commitment; T cell development; Thymocyte; Thymus; γδ T cells.

Publication types

Review

MeSH terms

Cell Differentiation
Cell Lineage
Humans
Receptors, Antigen, T-Cell, alpha-beta*
Receptors, Antigen, T-Cell, gamma-delta*
T-Lymphocytes
Thymus Gland

Substances

Receptors, Antigen, T-Cell, gamma-delta
Receptors, Antigen, T-Cell, alpha-beta