Increasing Use Of Interferon Gamma Release Assays Among Children ≥2 Years of Age in a Setting With Low Tuberculosis Prevalence

Pediatr Infect Dis J. 2022 Dec 1;41(12):e534-e537. doi: 10.1097/INF.0000000000003685. Epub 2022 Oct 10.


US guidelines recommend interferon gamma release assays (IGRAs) for diagnosis of tuberculosis infection in children. In this retrospective cohort study, IGRA use in children 2-17 years of age increased substantially between 2015 and 2021. Testing in inpatient/subspecialty settings (vs. primary care), public (vs. private) insurance, lower age and non-English preferred language were associated with increased odds of receiving an IGRA.

MeSH terms

  • Child
  • Humans
  • Interferon-gamma Release Tests
  • Latent Tuberculosis* / diagnosis
  • Mycobacterium tuberculosis*
  • Prevalence
  • Retrospective Studies
  • Tuberculin Test
  • Tuberculosis* / diagnosis
  • Tuberculosis* / epidemiology