The future of cardioneuroablation in cardiovascular medicine

Expert Rev Cardiovasc Ther. 2022 Nov;20(11):861-870. doi: 10.1080/14779072.2022.2147926. Epub 2022 Nov 15.


Introduction: Cardioneuroablation is increasingly being utilized to improve outcomes in patients with vagally mediated bradyarrhythmias. However, there are still controversial issues in the field including patient selection, safety and efficacy, and procedural end-points.

Areas covered: In this review, the current role of cardioneuroablation is summarized, and controversial issues related to the modality are discussed.

Expert opinion: According to small open-label cohort studies, overall freedom from syncope recurrence was higher than 90% after cardioneuroablation in patients with vasovagal syncope (VVS). Use of the electrogram-based strategy or high-frequency stimulation demonstrate similar success rate except in procedures limited to the right atrium. Based on a recently published randomized controlled trial and metanalysis, it may be possible now to make a strong recommendation for cardioneuroablation in patients <40 years of age, and those with the cardioinhibitory or mixed type of VVS who continue to experience frequent and/or burdensome syncope recurrences. Considering patients with VVS are prone to significant placebo/expectation effect, sham-controlled trials may help to quantify the placebo effect. In well-selected patients with functional atrioventricular block and sinus bradycardia, may result in encouraging medium-term outcomes. However, functional bradycardia is identified in a minority of patients presenting with high-grade atrioventricular block or sinus node dysfunction.

Keywords: Ablation; atrioventricular block; bradycardia; ganglionated plexus; pacemaker; syncope.

Publication types

  • Review

MeSH terms

  • Atrioventricular Block* / surgery
  • Bradycardia / surgery
  • Cardiovascular Agents*
  • Catheter Ablation* / methods
  • Humans
  • Sick Sinus Syndrome / surgery
  • Syncope, Vasovagal*


  • Cardiovascular Agents