The Emerging Pro-Algesic Profile of Transient Receptor Potential Vanilloid Type 4

Rev Physiol Biochem Pharmacol. 2023:186:57-93. doi: 10.1007/112_2022_75.


Transient receptor potential vanilloid type 4 (TRPV4) channels are Ca2+-permeable non-selective cation channels which mediate a wide range of physiological functions and are activated and modulated by a diverse array of stimuli. One of this ion channel's least discussed functions is in relation to the generation and maintenance of certain pain sensations. However, in the two decades which have elapsed since the identification of this ion channel, considerable data has emerged concerning its function in mediating pain sensations. TRPV4 is a mediator of mechanical hyperalgesia in the various contexts in which a mechanical stimulus, comprising trauma (at the macro-level) or discrete extracellular pressure or stress (at the micro-level), results in pain. TRPV4 is also recognised as constituting an essential component in mediating inflammatory pain. It also plays a role in relation to many forms of neuropathic-type pain, where it functions in mediating mechanical allodynia and hyperalgesia.Here, we review the role of TRPV4 in mediating pain sensations.

Keywords: Allodynia; Inflammatory pain; Mechanical hyperalgesia; Mechanotransduction; Neuropathic pain; Pain; Sensory processing; TRPV4.

Publication types

  • Review

MeSH terms

  • Antineoplastic Agents*
  • Humans
  • Hyperalgesia / drug therapy
  • Neuralgia*
  • TRPV Cation Channels / therapeutic use


  • TRPV Cation Channels
  • Antineoplastic Agents