Diagnostic challenge: Diffuse large B-cell lymphoma masquerading as orbital cellulitis

Trop Doct. 2023 Jan;53(1):97-99. doi: 10.1177/00494755221137628. Epub 2022 Nov 15.


We report a clinical case of orbital lymphoma masquerading as orbital cellulitis. Orbital lymphoma and lymphoma of the orbital adnexa are relatively rare types of lymphoma. They represent the malignant end of a spectrum of lymphoproliferative lesions that occur in the orbit, conjunctiva and eyelid. Diffuse large B-cell lymphomas (DLBCL) with variable clinical presentations have a relatively poor prognosis with rapid visual loss. Therefore, thorough evaluation and assessment with a multi-specialty effort are warranted for earlier diagnosis and initiation of treatment to save life and prevent sight loss.

Keywords: diffuse large B-cell lymphoma; orbital cellulitis; orbital lymphoma.

Publication types

  • Case Reports

MeSH terms

  • Humans
  • Lymphoma, Large B-Cell, Diffuse* / diagnosis
  • Lymphoma, Large B-Cell, Diffuse* / drug therapy
  • Lymphoma, Large B-Cell, Diffuse* / pathology
  • Orbit
  • Orbital Cellulitis* / diagnosis
  • Orbital Neoplasms* / diagnosis
  • Orbital Neoplasms* / pathology
  • Orbital Neoplasms* / therapy

Supplementary concepts

  • Orbital lymphoma