Fractional myocardial blood volume by ferumoxytol-enhanced MRI: Estimation of ischemic burden

Magn Reson Med. 2023 Apr;89(4):1557-1566. doi: 10.1002/mrm.29530. Epub 2022 Nov 16.


Purpose: To investigate model-fitted fractional myocardial blood volume (fMBV) derived from ferumoxytol-enhanced MRI as a measure of myocardial tissue hypoperfusion at rest.

Methods: We artificially induced moderate to severe focal coronary stenosis in the left anterior descending artery of 19 swine by percutaneous delivery of a 3D-printed coronary implant. Using the MOLLI pulse sequence, we acquired T1 maps at 3 T after multiple incremental ferumoxytol doses (0.0-4.0 mg/kg). We computed pixel-wise fMBV using a multi-compartmental modeling approach in 19 ischemic swine and 4 healthy swine.

Results: Ischemic myocardial segments showed a mean MRI-fMBV of 11.72 ± 3.00%, compared with 8.23 ± 2.12% in remote segments and 8.38 ± 2.23% in normal segments. Ischemic segments showed a restricted transvascular water-exchange rate (ki = 15.32 ± 8.69 s-1 ) relative to remote segments (ki = 17.78 [11.60, 26.36] s-1 ). A mixed-effects model found significant difference in fMBV (p = 0.002) and water-exchange rate (p < 0.001) between ischemic and remote myocardial regions after adjusting for biological sex and slice location. Analysis of fMBV as a predictor of impaired myocardial contractility using receiver operating characteristics showed an area under the curve of 0.89 (95% confidence interval [CI] 0.80, 0.95). An MRI-fMBV threshold of 9.60% has a specificity of 90.0% (95% CI 76.3, 97.2) and a sensitivity of 72.5% (95% CI 56.1, 83.4) for prediction of impaired myocardial contractility.

Conclusions: Model-fitted fMBV derived from ferumoxytol-enhanced MRI can distinguish regions of ischemia from remote myocardium in a swine model of myocardial hypoperfusion.

Keywords: blood volume; iron-based and other contrast agents; ischemic heart disease; myocardial perfusion; parametric mapping.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Blood Volume
  • Coronary Artery Disease*
  • Ferrosoferric Oxide
  • Ischemia
  • Magnetic Resonance Imaging
  • Myocardial Ischemia* / diagnostic imaging
  • Myocardium
  • Swine
  • Water


  • Ferrosoferric Oxide
  • Water