Myointimoma (angiocentric myofibroblastic tumor) of the glans penis in an adolescent: a case report and review of the literature

BMC Urol. 2022 Nov 16;22(1):186. doi: 10.1186/s12894-022-01131-3.


Background: Soft tumors of the penis are extremely rare in childhood and adolescence. Because there are no guidelines, each such case raises embarrassment over the extent and degree of aggressiveness of the diagnostic and therapeutic procedures. Herein, we describe a case of a teenager with a penile myointimoma along with a review of the literature. So far, only 10 cases have been reported in this age group.

Case presentation: The 15-year-old boy presented with a 6-months history of a slowly growing, palpable firm nodule in glans penis. Physical examination revealed a palpable, well circumscribed, firm, whitish painless mass, around 1 cm in diameter within the glans. Ultrasound revealed hypoechogenic, hypoperfused poorly defined area inside the glans. MRI did not confirm any other pathologic mass inside the glans and corpora cavernosa. An excisional biopsy was performed; its immunohistological features indicated myointimoma.

Discussion and conclusion: Given the rarity of this benign entity, the main importance is to distinguish myointioma from more clinically aggressive neoplasms. The key to a correct diagnosis is a careful histological examination, including immunohistochemistry. Local excision is safe and effective treatment modality.

Keywords: Adolescent; Case report; Myointimoma; Penile tumor.

Publication types

  • Review
  • Case Reports

MeSH terms

  • Adolescent
  • Biopsy
  • Humans
  • Immunohistochemistry
  • Male
  • Penile Neoplasms* / diagnostic imaging
  • Penile Neoplasms* / surgery
  • Penis / diagnostic imaging
  • Penis / pathology
  • Penis / surgery
  • Treatment Outcome