The role of ferroptosis in neurodegenerative diseases

Mol Biol Rep. 2023 Feb;50(2):1655-1661. doi: 10.1007/s11033-022-08048-y. Epub 2022 Nov 16.


Ferroptosis is newly identified as a non-apoptotic form of programmed cell death. It is characterized by iron-dependent intracellular accumulation of lipid peroxides which ultimately leads to oxidative stress and cell death. Ferroptosis has been identified in several diseases, such as cancer, renal failure, liver injury, and ischemia-reperfusion injury. Besides, it has been reported to be involved in the pathological mechanism of neurodegenerative diseases (NDD). In addition, interventions targeting ferroptosis can influence the course of NDD, making it a potential therapeutic target for NDD. By summarizing the current research on ferroptosis and its impact on many neurological diseases, we hope to provide valuable strategies for the underlying mechanisms and treatment of these neurological diseases.

Keywords: Alzheimer's disease; Amyotrophic lateral sclerosis; Ferroptosis; Huntington's disease; Neurodegenerative diseases; Parkinson's disease.

Publication types

  • Review

MeSH terms

  • Apoptosis
  • Cell Death
  • Ferroptosis* / genetics
  • Humans
  • Neurodegenerative Diseases*
  • Oxidative Stress / physiology