Clinico-Dermoscopic-Pathological Features of a Rare Case of Locally Invasive Multifocal Primary Cutaneous Diffuse Large B Cell Lymphoma-Leg Type Over the Face and Scalp

Biswanath Behera; Aparna Palit; Ashish Kumar Nayak; Ashutosh Panigrahi; Pritinanda Mishra; Madhusmita Sethy

doi:10.4103/ijd.IJD_783_20

Clinico-Dermoscopic-Pathological Features of a Rare Case of Locally Invasive Multifocal Primary Cutaneous Diffuse Large B Cell Lymphoma-Leg Type Over the Face and Scalp

Indian J Dermatol. 2022 May-Jun;67(3):283-286. doi: 10.4103/ijd.IJD_783_20.

Authors

Biswanath Behera¹, Aparna Palit¹, Ashish Kumar Nayak¹, Ashutosh Panigrahi², Pritinanda Mishra³, Madhusmita Sethy³

Affiliations

¹ Department of Dermatology, and Venereology, AIIMS, Bhubaneswar, Odisha, India.
² Department of Medical Oncology and Hematology, AIIMS, Bhubaneswar, Odisha, India.
³ Department of Pathology, AIIMS, Bhubaneswar, Odisha, India.

Abstract

Primary cutaneous diffuse large B-cell lymphoma-leg type (PCDLBCL-LT) is characterized by diffuse monotonous proliferation of centroblasts and immunoblasts. It commonly presents as erythematous to violaceous nodules on one or both the legs and has a poor prognosis. We report the clinico-dermoscopic-pathological features and therapeutic response of a rare case of PCDLBCL-LT in a 62-year-old diabetic man, who presented with multifocal plaques, one lobulated and two arcuate-shaped, on the face and scalp. During the investigation, one of the plaques had eroded the underlying bone without any evidence of malignant cells in the cerebrospinal fluid. He was successfully treated with R-CHOP (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone) along with intrathecal methotrexate.

Keywords: Dermoscopy; diffuse; large B-cell; lymphoma; skin neoplasms.

Publication types

Case Reports