The regulation of antiviral activity of interferon epsilon

Front Microbiol. 2022 Oct 25;13:1006481. doi: 10.3389/fmicb.2022.1006481. eCollection 2022.


Interferon epsilon (IFN-ε) is a type I IFN. Some biological properties has been identified in many species, such as antiproliferative, anti-tumor, and antiviral effects, of IFN-ε, which are much weaker than those of IFN-α, have also been revealed. It has been shown to play a role in mucosal immunity and bacterial infection and in the prevention of certain sexually transmitted diseases, such as human immunodeficiency virus (HIV). This paper reviews the known activity of IFN-ε, particularly in some viruses. In general, this review provides a better understanding of effective IFN-ε treatment in the future.

Keywords: antiviral; biological activities; interferon epsilon; type I IFNs; viral interference.

Publication types

  • Review