Lipid droplet - mitochondria coupling: A novel lipid metabolism regulatory hub in diabetic nephropathy

Ming Yang; Shilu Luo; Jinfei Yang; Wei Chen; Liyu He; Di Liu; Li Zhao; Xi Wang

doi:10.3389/fendo.2022.1017387

Lipid droplet - mitochondria coupling: A novel lipid metabolism regulatory hub in diabetic nephropathy

Front Endocrinol (Lausanne). 2022 Oct 25:13:1017387. doi: 10.3389/fendo.2022.1017387. eCollection 2022.

Authors

Ming Yang^{1

2}, Shilu Luo², Jinfei Yang², Wei Chen², Liyu He², Di Liu², Li Zhao³, Xi Wang^{1

4}

Affiliations

¹ Department of Nutrition, Xiangya Hospital, Central South University, Changsha, China.
² Department of Nephrology, The Second Xiangya Hospital of Central South University, Changsha, China.
³ Department of Reproduction and Genetics, The First Affiliated Hospital of Kunming Medical University, Kunming, China.
⁴ National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China.

Abstract

Diabetic nephropathy (DN) involves serious lipid metabolism disorder, and renal ectopic lipid deposition aggravates DN progression. However, the molecular mechanism of renal lipid deposition in DN remains unclear. Lipid droplets (LDs) are lipid pools in cells that change dynamically in response to the cellular energy needs. The LDs and mitochondria are connected through a part of the mitochondria known as the peridroplet mitochondria (PDM). In this review, we summarize the definition, detection methods, and function of the PDM. Finally, we discuss the research status of PDM in DN and the possibility of its use as a therapeutic target.

Keywords: diabetic nephropathy; lipid droplets; mitochondria; peridroplet mitochondria; β-oxidation.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Diabetes Mellitus* / metabolism
Diabetic Nephropathies* / metabolism
Humans
Lipid Droplets / metabolism
Lipid Metabolism / physiology
Lipids
Mitochondria / metabolism

Substances

Lipids