Mixed neuroendocrine/Non-neuroendocrine neoplasm (MiNEN) of gastrointestinal lineage arising in an ovarian mature cystic teratoma

Sandhyarani Dasaraju; Khalid Amin; Molly E Klein; Colleen Rivard; Jordan Mattson; Sarah Davidson; Mahmoud A Khalifa

doi:10.1016/j.gore.2022.101099

Mixed neuroendocrine/Non-neuroendocrine neoplasm (MiNEN) of gastrointestinal lineage arising in an ovarian mature cystic teratoma

Gynecol Oncol Rep. 2022 Nov 5:44:101099. doi: 10.1016/j.gore.2022.101099. eCollection 2022 Dec.

Authors

Sandhyarani Dasaraju¹, Khalid Amin¹, Molly E Klein¹, Colleen Rivard², Jordan Mattson², Sarah Davidson², Mahmoud A Khalifa¹

Affiliations

¹ Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN 55455, US.
² Division of Gynecologic Oncology, Department of Obstetrics, Gynecology and Women's Health, University of Minnesota, Minneapolis, MN 55455, USA.

Abstract

•Mixed neuroendocrine/non-neuroendocrine neoplasm (MiNEN) of gastrointestinal lineage arising in an ovarian mature cystic teratoma is extremely rare.•It is important to differentiate the gastrointestinal-type adenocarcinoma arising along with neuroendocrine tumor from a primary mucinous adenocarcinoma of the ovary. SATB2 and CDX2 Immunohistochemical stains play important role in differentiate these two.•This case highlights the careful morphologic evaluation and extensive sampling is crucial to make this rare diagnosis.

Keywords: Adenocarcinoma; Malignant transformation; MiNEN; Neuroendocrine tumor; Teratoma.

Publication types

Case Reports