N and N'-mediated recognition confers resistance to tomato brown rugose fruit virus

MicroPubl Biol. 2022 Oct 29;2022:10.17912/micropub.biology.000660. doi: 10.17912/micropub.biology.000660. eCollection 2022.


Tomato brown rugose fruit virus (ToBRFV) is an emerging tobamovirus that overcomes the Tm-2 2 resistance gene used in commercial tomato plants to protect against tobamoviruses. In this article, we show that ToBRFV is recognised through its P50 replicase fragment by the resistance gene N in N. tabacum , which triggers a hypersensitive response (HR). We also demonstrate that the N' gene provides protection against ToBRFV through recognition of the viral coat protein without triggering a typical HR in N. tabacum .