Myeloid checkpoints for cancer immunotherapy

Chin J Cancer Res. 2022 Oct 30;34(5):460-482. doi: 10.21147/j.issn.1000-9604.2022.05.07.


Myeloid checkpoints are receptors on the myeloid cell surface which can mediate inhibitory signals to modulate anti-tumor immune activities. They can either inhibit cellular phagocytosis or suppress T cells and are thus involved in the pathogenesis of various diseases. In the tumor microenvironment, besides killing tumor cells by phagocytosis or activating anti-tumor immunity by tumor antigen presentation, myeloid cells could execute pro-tumor efficacies through myeloid checkpoints by interacting with counter-receptors on other immune cells or cancer cells. In summary, myeloid checkpoints may be promising therapeutic targets for cancer immunotherapy.

Keywords: Cancer; MDSC; TAM; immune checkpoint; immunotherapy; myeloid checkpoint.