In this work, an effective method was explored to prepare silver nanoparticles/graphene oxide-sulfobutylether-β-cyclodextrin (AgNPs/GO-SBE-β-CD) antibacterial nanocomposite. Dopamine (DA) was used as a green and mild reductant to directly in situ reduce silver nitrate on Sulfobutylether-β-cyclodextrin (SBE-β-CD) modified graphene oxide (GO-SBE-β-CD). Its synthesized, antibacterial properties and biocompatibility were studied. Results showed that silver nanoparticles with an average size of 73 nm were uniformly distributed on the GO-SBE-β-CD sheets. In addition, AgNPs/GO-SBE-β-CD were proved an effective antibacterial material against both gram-negative and gram-positive, reduced the viability of E. coli and S. aureus by 90 % at 40 µg/mL. At the same time, AgNPs/GO-SBE-β-CD co-cultured with L929 cells did not show cytotoxicity. In vivo experiment, AgNPs/GO-SBE-β-CD showed good biocompatibility. Collectively, AgNPs/GO-SBE-β-CD is a promising material to prevent bacterial infection, expecting to be applied in wound healing.
Keywords: Antibacterial activity; Biocompatibility; Graphene oxide; Silver nanoparticles; Sulfobutylether-β-cyclodextrin.
Copyright © 2022. Published by Elsevier B.V.