Valvular Heart Disease: New Concepts in Pathophysiology and Therapeutic Approaches

Annu Rev Med. 2023 Jan 27:74:155-170. doi: 10.1146/annurev-med-042921-122533. Epub 2022 Nov 18.


This review discusses recent advancements in the field of valvular heart disease. Topics covered include recognition of the impact of atrial fibrillation on development and assessment of valvular disease, strategies for global prevention of rheumatic heart disease, understanding and management of secondary mitral regurgitation, the updated classification of bicuspid aortic valve disease, recognition of heightened cardiovascular risk associated with moderate aortic stenosis, and a growing armamentarium of transcatheter therapies.

Keywords: aortic stenosis; bicuspid aortic valve disease; mitral regurgitation; mitral stenosis; rheumatic heart disease; tricuspid regurgitation.

Publication types

  • Review

MeSH terms

  • Aortic Valve Stenosis* / therapy
  • Atrial Fibrillation*
  • Bicuspid Aortic Valve Disease* / complications
  • Heart Valve Diseases* / therapy
  • Humans
  • Mitral Valve Insufficiency* / therapy