Little evidence supports gabapentinoid use in bipolar disorder or insomnia

BMJ. 2022 Nov 18:379:o2576. doi: 10.1136/bmj.o2576.

Abstract

The studyHong JSW, Atkinson LZ, Al-Juffali N, et al. Gabapentin and pregabalin in bipolar disorder, anxiety states, and insomnia: systematic review, meta-analysis, and rationale. Mol Psychiatry 2022;27:1339-49.To read the full NIHR Alert, go to: https://evidence.nihr.ac.uk/alert/review-finds-little-evidence-support-gabapentinoid-use-bipolar-disorder-or-insomnia/.

Publication types

  • Systematic Review
  • Meta-Analysis

MeSH terms

  • Bipolar Disorder* / drug therapy
  • Gabapentin / therapeutic use
  • Humans
  • Pregabalin / therapeutic use
  • Sleep Initiation and Maintenance Disorders* / drug therapy

Substances

  • Gabapentin
  • Pregabalin