Chronic Hepatitis B Virus and Hepatitis D Virus: New Developments

Clin Liver Dis. 2023 Feb;27(1):17-25. doi: 10.1016/j.cld.2022.08.001. Epub 2022 Oct 18.

Abstract

Hepatitis B virus (HBV) and hepatitis D virus are leading causes of morbidity and mortality worldwide. Despite the availability of HBV vaccinations that are 98% to 100% effective, an estimated 820,000 annual deaths were attributed to HBV in 2019, mainly related to the sequelae of cirrhosis and hepatocellular carcinoma. Because disease prevalence is concentrated outside of the United States, it is overlooked, but with expanded vaccination recommendations provided by the Centers for Disease Control and Prevention and recommended screening, as well as heightened awareness by health care providers, we can work toward the eradication of this preventable disease.

Keywords: Antivirals; Hepatitis B; Hepatitis D; Hepatitis delta; Vaccination.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Carcinoma, Hepatocellular* / epidemiology
  • Carcinoma, Hepatocellular* / etiology
  • Carcinoma, Hepatocellular* / prevention & control
  • Hepatitis B virus
  • Hepatitis B, Chronic* / complications
  • Hepatitis B, Chronic* / epidemiology
  • Hepatitis B, Chronic* / prevention & control
  • Hepatitis Delta Virus
  • Humans
  • Liver Neoplasms* / epidemiology
  • Liver Neoplasms* / etiology
  • Liver Neoplasms* / prevention & control
  • United States / epidemiology