Evaluation of Cerebellar Ataxic Patients

Neurol Clin. 2023 Feb;41(1):21-44. doi: 10.1016/j.ncl.2022.05.002. Epub 2022 Aug 31.


Cerebellar ataxia results from damage to the cerebellum and presents as movement incoordination and variability, gait impairment, and slurred speech. Patients with cerebellar ataxia can also have cognitive and mood changes. Although the identification of causes for cerebellar ataxia can be complex, age of presentation, chronicity, family history, and associated movement disorders may provide diagnostic clues. There are many genetic causes for cerebellar ataxia, and the common autosomal dominant and recessive ataxia are due to genetic repeat expansions. Step-by-step approach will lead to the identification of the causes. Symptomatic and potential disease-modifying therapies may benefit patients with cerebellar ataxia.

Keywords: Ataxia; Cerebellar ataxia; Genetics; Multiple system atrophy; Spinocerebellar ataxia.

Publication types

  • Review

MeSH terms

  • Ataxia
  • Cerebellar Ataxia* / diagnosis
  • Cerebellar Ataxia* / genetics
  • Cerebellum
  • Humans