Cam-post dislocations are a unique complication of total knee arthroplasty (TKA) designs that utilize a cam-post mechanism, representing an extreme form of deep flexion instability. They are rare complications and are poorly defined in the existing literature. The purpose of this case study is to present a series of six cam-post dislocation cases to improve understanding of this complication and its mechanism, presentation, and available treatment options. All patients experienced cam-post dislocations after a deep flexion moment that were identified clinically and confirmed radiographically. Affected implants included both primary and revision components and all utilized a cam-post mecha- nism. Three patients underwent revision surgery whereas the remaining three were treated with closed reduction only. Cam-post dislocations are rare complications of posterior- stabilized TKA that should be understood and recognized by adult reconstruction surgeons. Closed reduction may be achieved with hyperflexion and anterior drawer or with hyperextension, but these patients may ultimately require a revision procedure.