Mast cells as important regulators in the development of psoriasis

Front Immunol. 2022 Nov 3:13:1022986. doi: 10.3389/fimmu.2022.1022986. eCollection 2022.


Psoriasis is a chronic inflammatory immune skin disease mediated by genetic and environmental factors. As a bridge between innate and adaptive immunity, mast cells are involved in the initiation, development, and maintenance of psoriasis by interactions and communication with a variety of cells. The current review describes interactions of mast cells with T cells, Tregs, keratinocytes, adipocytes, and sensory neurons in psoriasis to emphasize the important role of mast cell-centered cell networks in psoriasis.

Keywords: T cell; cell network; inflammation; mast cell; psoriasis.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adaptive Immunity
  • Humans
  • Keratinocytes
  • Mast Cells*
  • Psoriasis*
  • Skin