Dual NHC/photoredox catalytic synthesis of 1,4-diketones using an MR-TADF photocatalyst (DiKTa)

Callum Prentice; James Morrison; Eli Zysman-Colman; Andrew D Smith

doi:10.1039/d2cc05705k

Dual NHC/photoredox catalytic synthesis of 1,4-diketones using an MR-TADF photocatalyst (DiKTa)

Chem Commun (Camb). 2022 Dec 8;58(98):13624-13627. doi: 10.1039/d2cc05705k.

Authors

Callum Prentice^{1

2}, James Morrison³, Eli Zysman-Colman¹, Andrew D Smith²

Affiliations

¹ Organic Semiconductor Centre, EaStCHEM, School of Chemistry University of St Andrews, St Andrews, Fife, KY16, 9ST, UK. eli.zysman-colman@st-andrews.ac.uk.
² EaStCHEM, School of Chemistry, University of St Andrews, North Haugh, Fife, Scotland, KY16 9ST, UK. ads10@st-andrews.ac.uk.
³ Pharmaceutical Sciences, IMED Biotech Unit, Astra Zeneca, Macclesfield, SK10 2NA, UK.

PMID: 36408774
DOI: 10.1039/d2cc05705k

Abstract

The use of the recently reported organic multi-resonant thermally activated delayed fluorescence (MR-TADF) photocatalyst DiKTa allows for the modular synthesis of 1,4-diketones under mild and metal-free conditions. The reaction proceeds via a three-component relay process in the presence of an N-heterocyclic carbene (NHC) organocatalyst.