Interdisciplinary care of children with diffuse midline glioma

Christina Coleman; Katherine Chen; Alex Lu; Elizabeth Seashore; Schuyler Stoller; Taron Davis; Steve Braunstein; Nalin Gupta; Sabine Mueller

doi:10.1016/j.neo.2022.100851

Interdisciplinary care of children with diffuse midline glioma

Neoplasia. 2023 Jan:35:100851. doi: 10.1016/j.neo.2022.100851. Epub 2022 Nov 18.

Authors

Christina Coleman¹, Katherine Chen², Alex Lu³, Elizabeth Seashore¹, Schuyler Stoller⁴, Taron Davis⁵, Steve Braunstein², Nalin Gupta⁶, Sabine Mueller⁷

Affiliations

¹ Department of Pediatrics, University of California, San Francisco, United States.
² Department of Radiation Oncology, University of California, San Francisco, United States.
³ Department of Neurological Surgery, University of California, San Francisco, United States.
⁴ Department of Neurology, University of California, San Francisco, United States.
⁵ Department of Orthopedic Surgery, University of California, San Francisco, United States.
⁶ Department of Pediatrics, University of California, San Francisco, United States; Department of Neurological Surgery, University of California, San Francisco, United States.
⁷ Department of Pediatrics, University of California, San Francisco, United States; Department of Neurological Surgery, University of California, San Francisco, United States; Department of Neurology, University of California, San Francisco, United States; Department of Pediatrics, University of Zurich, Zurich, Switzerland. Electronic address: sabine.mueller@ucsf.edu.

Abstract

Diffuse Midline Glioma (DMG) which includes Diffuse Intrinsic Pontine Glioma (DIPG) is an infiltrative tumor of the midline structures of the central nervous system that demonstrates an aggressive pattern of growth and has no known curative treatment. As these tumors progress, children experience ongoing neurological decline including inability to ambulate, swallow and communicate effectively. We propose that optimal care for patients with DMG should involve a specialized team experienced in caring for the multifaceted needs of these patients and their families. Herein we review the roles and evidence to support early involvement of a specialized interdisciplinary team and outline our views on best practices for these challenging tumors.

Keywords: Best practices; DIPG; Diffuse Midline glioma; Interdisciplinary care.

Publication types

Review

MeSH terms

Brain Stem Neoplasms* / diagnosis
Brain Stem Neoplasms* / pathology
Brain Stem Neoplasms* / therapy
Child
Glioma* / diagnosis
Glioma* / genetics
Glioma* / therapy
Humans