Interdisciplinary care of children with diffuse midline glioma

Neoplasia. 2023 Jan;35:100851. doi: 10.1016/j.neo.2022.100851. Epub 2022 Nov 18.


Diffuse Midline Glioma (DMG) which includes Diffuse Intrinsic Pontine Glioma (DIPG) is an infiltrative tumor of the midline structures of the central nervous system that demonstrates an aggressive pattern of growth and has no known curative treatment. As these tumors progress, children experience ongoing neurological decline including inability to ambulate, swallow and communicate effectively. We propose that optimal care for patients with DMG should involve a specialized team experienced in caring for the multifaceted needs of these patients and their families. Herein we review the roles and evidence to support early involvement of a specialized interdisciplinary team and outline our views on best practices for these challenging tumors.

Keywords: Best practices; DIPG; Diffuse Midline glioma; Interdisciplinary care.

Publication types

  • Review

MeSH terms

  • Brain Stem Neoplasms* / diagnosis
  • Brain Stem Neoplasms* / pathology
  • Brain Stem Neoplasms* / therapy
  • Child
  • Glioma* / diagnosis
  • Glioma* / genetics
  • Glioma* / therapy
  • Humans