Cutaneous Oncology in the Immunosuppressed

Dermatol Clin. 2023 Jan;41(1):141-162. doi: 10.1016/j.det.2022.07.012.


Patients with immunosuppressive conditions experience an increased frequency and severity of cutaneous malignancies. This article highlights management of keratinocyte carcinoma, melanoma, Merkel cell carcinoma, and Kaposi sarcoma in the setting of lymphoproliferative disorders, acquired immunodeficiencies, and organ transplantation. Advances in the safety of organ transplant recipient immunosuppression, early identification of risk factors, and new targeted therapies are improving skin cancer outcomes in immunocompromised populations.

Keywords: Chronic lymphocytic leukemia; HIV; Immunosuppression; Kaposi sarcoma; Keratinocyte carcinoma; Melanoma; Merkel cell carcinoma; Organ transplant recipients.

Publication types

  • Review

MeSH terms

  • Carcinoma, Merkel Cell* / therapy
  • Humans
  • Immunocompromised Host
  • Immunosuppression Therapy / adverse effects
  • Skin / pathology
  • Skin Neoplasms* / pathology