Micro lesion effect of pallidal deep‑brain stimulation for meige syndrome

Sci Rep. 2022 Nov 21;12(1):19980. doi: 10.1038/s41598-022-23156-2.


To analyse the microlesion effect (MLE) in the globus pallidus interna (GPi) of deep brain stimulation (DBS) in patients with Meige syndrome. Thirty-two patients with primary Meige syndrome who underwent GPi-DBS in this study. Burke-Fahn-Marsden Dystonia Rating Scale scores (BFMDRS-M) were obtained for the evaluation of clinical symptoms at 3 days before DBS (baseline), 24 h after DBS surgery, once weekly for 1 month until electrical stimulation, 6 months postoperatively and 12 months after surgery. Twenty-seven patients had MLE after GPi-DBS. The mean time of BFMDRS-M scores maximal improvement from MLE was 35.9 h postoperatively (range, 24-48 h), and the mean scores improved by 49.35 ± 18.16%. At 12 months after surgery, the mean BFMDRS-M scores improved by 50.28 ± 29.70%. There was a positive correlation between the magnitude of MLE and the motor score at 12 months after GPi-DBS (R2 = 0.335, p < 0.05). However, there was no correlation between the duration of MLE and DBS improvement. Most Meige syndrome patients who underwent GPi-DBS and had MLE benefited from MLE. For Meige syndrome, MLE might be a predictive factor for patient clinical symptom improvement from DBS.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Deep Brain Stimulation* / adverse effects
  • Dystonia*
  • Globus Pallidus / physiology
  • Globus Pallidus / surgery
  • Humans
  • Meige Syndrome* / therapy
  • Treatment Outcome

Supplementary concepts

  • Fatty Acid Hydroxylase-Associated Neurodegeneration