Trigeminal trophic syndrome in a pediatric patient with diffuse intrinsic pontine glioma

Pediatr Dermatol. 2022 Nov 21. doi: 10.1111/pde.15164. Online ahead of print.


A 13-year-old girl with a history of diffuse intrinsic pontine glioma (DIPG) suffered from progressively worsening facial ulcerations secondary to paresthesia-induced self-excoriation. She was diagnosed with trigeminal trophic syndrome (TTS) induced by DIPG and struggled to heal her lesions in the background of this excoriation disorder. A multidisciplinary approach that included mood disorder management with sertraline and amitriptyline helped diminish paresthesia, improve her quality of life, and promote healing of the ulcers despite the progression of her DIPG. This case highlights the multifactorial complexity of TTS in pediatric patients and the need for successful management strategies.

Keywords: cervical trophic syndrome; diffuse intrinsic pontine glioma; paresthesia; skin ulcer; trigeminal nerve; trigeminal nerve disorder; trophic syndrome.

Publication types

  • Case Reports