Imidazole and Derivatives Drugs Synthesis: A Review

Curr Org Synth. 2023;20(6):630-662. doi: 10.2174/1570179420666221118100525.

Abstract

Imidazoles have long held a special place in heterocyclic chemistry, and their derivatives have piqued interest in recent years due to their diverse chemistry and pharmacology features. Imidazole is a biologically and pharmaceutically important nitrogen-containing heterocyclic ring. As a result, researchers have been interested in imidazole molecules. For a century and a half, purine, histamine, and other natural compounds all contained the imidazole ring. A number of imidazole drugs have been prepared and marketed for the treatment of various diseases. In view of this, we herein report a detailed account of synthetic procedures for various imidazole drugs.

Keywords: Azole; derivatives drugs; drugs synthesis; imidazole; imidazole drugs; marketed drugs.

Publication types

  • Review

MeSH terms

  • Histamine* / chemistry
  • Imidazoles* / pharmacology

Substances

  • imidazole
  • Imidazoles
  • Histamine