A Glimpse of necroptosis and diseases

Biomed Pharmacother. 2022 Dec;156:113925. doi: 10.1016/j.biopha.2022.113925. Epub 2022 Oct 27.

Abstract

Programmed cell death plays an important role in maintaining homeostasis. Necroptosis is a type of programmed cell death that has been recently discovered. It is mediated by RIPK1, RIPK3, and MLKL, and is characterized by necrotic cell morphology. Interestingly, the abnormal activation of necroptosis could lead to inflammation and a variety of diseases. In this study, we reviewed the molecular mechanism underlying necroptosis, and discuss its role in the pathogenesis of various diseases. Finally, we summarize several current inhibitors of necroptosis and discuss the potential of targeting necroptosis as a therapeutic strategy for various diseases.

Keywords: Inflammation; MLKL; Necroptosis; Programmed cell death; RIPK1.

Publication types

  • Review

MeSH terms

  • Apoptosis
  • Humans
  • Inflammation / pathology
  • Necroptosis*
  • Necrosis / pathology
  • Protein Kinases* / metabolism

Substances

  • Protein Kinases