Challenging Myelopathy Cases

Semin Neurol. 2022 Dec;42(6):723-734. doi: 10.1055/a-1985-0124. Epub 2022 Nov 23.


Misdiagnosis of myelopathies is common and can lead to irreversible disability when diagnosis- and disease-specific treatments are delayed. Therefore, quickly determining the etiology of myelopathy is crucial. Clinical evaluation and MRI spine are paramount in establishing the correct diagnosis and subsequently an appropriate treatment plan. Herein, we review an approach to myelopathy diagnosis focused on the time course of neurologic symptom progression and neuroimaging pearls, and apply them to a variety of inflammatory, structural, and vascular myelopathy cases.

Publication types

  • Review
  • Research Support, N.I.H., Extramural

MeSH terms

  • Diagnosis, Differential
  • Humans
  • Magnetic Resonance Imaging / adverse effects
  • Neuroimaging / adverse effects
  • Spinal Cord Diseases* / diagnostic imaging
  • Spinal Cord Diseases* / etiology