Parental Attitudes and Perceptions of Support after Brief Clinician Intervention Predict Intentions to Accept the Adjuvanted Seasonal Influenza Vaccination: Findings from the Pediatric Influenza Vaccination Optimization Trial (PIVOT)-I

William A Fisher; Vladimir Gilca; Michelle Murti; Alison Orth; Hartley Garfield; Paul Roumeliotis; Emmanouil Rampakakis; Vivien Brown; John Yaremko; Paul Van Buynder; Constantina Boikos; James A Mansi

doi:10.3390/vaccines10111957

Parental Attitudes and Perceptions of Support after Brief Clinician Intervention Predict Intentions to Accept the Adjuvanted Seasonal Influenza Vaccination: Findings from the Pediatric Influenza Vaccination Optimization Trial (PIVOT)-I

Vaccines (Basel). 2022 Nov 18;10(11):1957. doi: 10.3390/vaccines10111957.

Authors

Affiliations

¹ Department of Psychology, Department of Obstetrics and Gynaecology, Western University, London, ON N6A 3K7, Canada.
² Département de Médecine Sociale et Préventive, Faculté de Médecine, Institut Nationale de Sante Publique du Québec and Université Laval, Québec City, QC G1V 5B3, Canada.
³ Dalla Lana School of Public Health, University of Toronto, Toronto, ON M5T 3M7, Canada.
⁴ Fraser Health Authority, Vancouver, BC V3T 0H1, Canada.
⁵ The Hospital for Sick Children, University of Toronto, Toronto, ON M5G 1X8, Canada.
⁶ Eastern Ontario Health Unit, Cornwall, ON K6J 5T1, Canada.
⁷ JSS Medical Research, Montreal, QC H4S 1N8, Canada.
⁸ Department of Family and Community Medicine, University of Toronto, Toronto, ON M5G 1V7, Canada.
⁹ The Montreal Children's Hospital, Montreal, QC H4A 3J1, Canada.
¹⁰ Department of Pediatrics, McGill University, Montreal, QC H3A 0G4, Canada.
¹¹ School of Medicine, Griffith University, University of Western Australia, Perth, WA 6009, Australia.
¹² Seqirus, Montreal, QC H9H 4M7, Canada.

Abstract

Adjuvanted trivalent influenza vaccine (aTIV) provides enhanced protection against seasonal influenza in children compared with nonadjuvanted trivalent influenza vaccine (TIV). This prospective cohort study assessed parental attitudes, beliefs, and intentions to vaccinate their infants aged 6-23 months with aTIV. Parents were surveyed before and after routine healthy baby visits, and post clinician interaction results were analyzed using multivariable logistic regression. Physicians at 15 community practice clinics and nurses at 3 public health clinics participated; 207 parents were surveyed. After clinician consultation, most parents considered immunization with aTIV to be safe (72.9%), effective (69.6%), and important (69.0%); most perceived support for vaccination from significant others (62.8%) and clinicians (81.6%); and 66.6% intended to vaccinate their infant with aTIV. Parental attitudes toward vaccinating their infant with aTIV were strongly correlated with perceptions of vaccine safety, efficacy, and importance, and these represented the strongest influence on intentions to vaccinate (odds ratio (OR) 79.25; 95% confidence interval (CI) 6.05-1037.50). Parental intentions were further influenced by perceived strength of clinician recommendation (OR 4.55, 95% CI 1.38-15.06) and social support for vaccination (OR 3.46, 95% CI 0.50-24.13). These findings may inform clinician approaches to parental education to ensure optimal seasonal pediatric influenza vaccination.

Keywords: adjuvanted; immunization; influenza; parental acceptance; pediatric; vaccine hesitancy.

Grants and funding

This study was funded by Novartis Vaccines and Diagnostics, Inc. and Seqirus Inc. Of note, Novartis’ influenza vaccine business was acquired by the CSL-group on 31 July 2015, and currently operates as Seqirus, Inc. The sponsor had primary responsibility for study design, protocol development, study monitoring, data management, and statistical analyses.