The Evaluation of Lymphadenopathy in a Resource-Limited Setting

Cureus. 2022 Oct 24;14(10):e30623. doi: 10.7759/cureus.30623. eCollection 2022 Oct.


Lymphadenopathy (LAP) refers to abnormalities in the size or consistency of lymph nodes. A wide range of etiologies contributes to the difficulty in diagnosing LAP, from mild self-limited viral infections to grave autoimmune diseases and malignancies. Detailed history-taking and a thorough physical examination are essential. Some physicians in developing countries may consider therapeutic testing. Certain groups may require additional evaluations and special treatment. When treating LAP, the etiology is targeted, but corticosteroids should not be administered before a complete diagnosis has been established due to their ability to mask the histological diagnosis of lymphoma and malignancy. This review aims to provide more straightforward and affordable methods available in almost all healthcare settings, especially those with limited resources.

Keywords: clinical evaluation; etiology and treatment; lymph node lesion; peripheral lymphadenopathy; reactive lymphadenopathy; resource-limited setting; unilateral hilar lymphadenopathy.

Publication types

  • Review