Prevalence of dog erythrocyte antigen 1 in a population of dogs tested in California

J Vet Emerg Crit Care (San Antonio). 2023 Mar;33(2):267-271. doi: 10.1111/vec.13263. Epub 2022 Nov 25.


Background: Multiple studies have evaluated the breed-specific prevalence of dog erythrocyte antigen (DEA) 1 in various geographic regions. However, few large-scale studies exist that describe breed prevalence of DEA 1 in the United States.

Key findings: From January 2000 to October 2020, 6469 dogs had their RBC antigen type determined and were included in the study. The overall prevalence of DEA 1 in all dogs was 61.2%. Of 50 breeds with sample sizes ≥20, 8 breeds had a high prevalence (≥90%) of DEA 1-positive blood type: Basset Hound, Bernese Mountain Dog, Brittany, Dachshund, Miniature Pinscher, Miniature Schnauzer, Pug, and Rottweiler. Four breeds had a high prevalence (≥90%) of DEA 1-negative blood type: Boxer, English Bulldog, Flat-Coated Retriever, and French Bulldog. Numerous breeds with a sample size <20 and ≥5 were found to have 100% prevalence of a DEA 1 blood type, although these findings need to be confirmed with a larger sample size. No statistical difference in any breed based on sex was found. The results in this study are consistent with previously reported data in other countries.

Significance: Knowledge of regional breed differences in DEA 1 prevalence can help to improve selection and recruitment of appropriate blood donor dogs.

Keywords: DEA; acute hemolytic transfusion reaction; blood type; red blood cells; transfusion.

MeSH terms

  • Animals
  • Blood Group Antigens*
  • Blood Group Incompatibility / veterinary
  • Blood Grouping and Crossmatching / veterinary
  • Blood Transfusion / veterinary
  • California / epidemiology
  • Dog Diseases* / epidemiology
  • Dogs
  • Erythrocytes
  • Prevalence


  • Blood Group Antigens