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. 2022 Dec:65:102969.
doi: 10.1016/j.scr.2022.102969. Epub 2022 Nov 14.

Generation of three induced pluripotent stem cell lines to model and investigate diseases affecting Hispanics

Ian Y Chen  1 , Joseph Olshausen  1 , Dilip Thomas  2 , Celine Lai  3 , Tracey L McLaughlin  4 , Joseph C Wu  5
Affiliations

Generation of three induced pluripotent stem cell lines to model and investigate diseases affecting Hispanics

Ian Y Chen et al. Stem Cell Res. 2022 Dec.

Abstract

Hispanics are the fastest-growing minority group in the United States. There has been a burgeoning interest in understanding the reasons underlying health disparities among this population. To facilitate the modeling and investigation of diseases that differentially impact Hispanics, we generated three induced pluripotent stem cell (iPSC) lines from the peripheral blood mononuclear cells (PBMCs) of healthy Hispanic subjects. All three lines exhibited normal morphology and karyotypes, robust expression of pluripotency markers, and the capacity for trilineage differentiation. The derivatives of these lines will serve as valuable ethnic-appropriate cell sources for further mechanistic studies on diseases impacting Hispanics.

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Conflict of interest statement

Declaration of Competing Interest J.C.W. is a co-founder of Khloris Biosciences; however, the work done here is completely independent. The other authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

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References

    1. Medina-Inojosa J, Jean N, Cortes-Bergoderi M, Lopez-Jimenez F, 2014. The Hispanic paradox in cardiovascular disease and total mortality. Prog Cardiovasc Dis. 57, 286–292. - PubMed
    1. Mullen M, Zhang A, Lui GK, Romfh AW, Rhee JW, Wu JC, 2021. Race and genetics in congenital heart disease: application of iPSCs, omics, and machine learning technologies. Front Cardiovasc Med. 8, 635280. - PMC - PubMed
    1. Roman Y, 2022. The United States 2020 Census data: implications for precision medicine and the research landscape. Per Med. 19, 5–8. - PubMed
    1. Sallam K, Thomas D, Gaddam S, Lopez N, Beck A, Beach L, Rogers AJ, Zhang H, Chen IY, Ameen M, Hiesinger W, Teuteberg JJ, Rhee JW, Wang KC, Sayed N, Wu JC, 2022. Modeling effects of immunosuppressive drugs on human hearts using induced pluripotent stem cell-derived cardiac organoids and single-cell RNA sequencing. Circulation 145, 1367–1369. - PMC - PubMed
    1. Velasco-Mondragon E, Jimenez A, Palladino-Davis AG, Davis D, Escamilla-Cejudo JA, 2016. Hispanic health in the USA: a scoping review of the literature. Public Health Rev. 37, 31. - PMC - PubMed

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