The relationship between perceived stress and symptom patterns was investigated in 136 seventh and eighth grade boys and girls. Affective-oriented coping and social support, two variables hypothesized as mediators of this relationship, were examined also. Participants completed the Modified Adolescent Life Change Events Questionnaire, the Jalowiec Coping Scale, the PRQ-A Social Support System, and the Symptom Pattern Scale. As predicted, the positive relationship between perceived stress and symptom patterns decreased when controlling for affective-oriented coping, while it increased when controlling for social support. Implications for nursing practice and further theory development are discussed.