Imaging of extrapontine myelinolysis preceding central pontine myelinolysis in a case of ornithine transcarbamylase deficiency with hyperammonaemia and hypokalaemia

Yuya Tanaka; Mitsuru Matsuki; Rieko Furukawa; Waka Nakata; Yoshio Sakurai; Sayaka Ajihara; Akiko Kawano; Harushi Mori

doi:10.1136/bmjno-2022-000354

Imaging of extrapontine myelinolysis preceding central pontine myelinolysis in a case of ornithine transcarbamylase deficiency with hyperammonaemia and hypokalaemia

BMJ Neurol Open. 2022 Nov 22;4(2):e000354. doi: 10.1136/bmjno-2022-000354. eCollection 2022.

Authors

Yuya Tanaka^{1

2}, Mitsuru Matsuki³, Rieko Furukawa³, Waka Nakata³, Yoshio Sakurai⁴, Sayaka Ajihara⁵, Akiko Kawano⁴, Harushi Mori^{1

2}

Affiliations

¹ Department of Radiology, Jichi Medical University, Shimotsuke, Tochigi, Japan.
² Department of Radiology, The University of Tokyo, Bunkyo, Tokyo, Japan.
³ Department of Pediatric Medical Imaging, Jichi Children's Medical Center Tochigi, Shimotsuke, Tochigi, Japan.
⁴ Department of Pediatrics, Saitama Medical Center, Kawagoe, Saitama, Japan.
⁵ Department of Pediatrics & Clinical Genomics, Saitama Medical University, Iruma, Saitama, Japan.

Abstract

Background: Patients with ornithine transcarbamylase deficiency (OTCD) often present with severe hyperammonaemia. We report a case of osmotic demyelination syndrome (ODS) secondary to the treatment of hyperammonaemia due to OTCD, a disease requiring early diagnosis, as it can have a severe prognosis.

Case: A girl toddler was brought to the hospital with a complaint of somnolence, presenting with hyperammonaemia and liver failure, and was diagnosed with OTCD. Treatment was started immediately, and the ammonia level returned to the normal range within 24 hours. On days 13-20, another treatment was commenced for re-elevated ammonia levels, which subsequently returned to within the reference range; however, mildly impaired consciousness persisted. Hypokalaemia coincided with temporary intravenous treatment and continuous haemodialysis. T2-weighted magnetic resonance images revealed lesions as high-signal areas in the bilateral putamen on day 11 (extrapontine myelinolysis (EPM)) and in the pons on day 51 (central pontine myelinolysis (CPM)). Consequently, ODS was diagnosed.

Conclusion: When interpreting magnetic resonance images of patients under acute treatment for hyperammonaemia due to OTCD, a condition that may be complicated by hypokalaemia, paying attention to findings suggesting EPM may help detect ODS before CPM appears and may improve patient prognosis.

Keywords: METABOLIC DISEASE; MRI; MYELOPATHY; NEURORADIOLOGY; PAEDIATRIC.