Contouring lumbosacral plexus nerves with MR neurography and MR/CT deformable registration technique

Xi Cao; Xian-Shu Gao; Wei Li; Peilin Liu; Shang-Bin Qin; Yan-Bin Dou; Hong-Zhen Li; Shiyu Shang; Xiao-Bin Gu; Ming-Wei Ma; Xin Qi; Mu Xie; Dian Wang

doi:10.3389/fonc.2022.818953

Contouring lumbosacral plexus nerves with MR neurography and MR/CT deformable registration technique

Front Oncol. 2022 Nov 9:12:818953. doi: 10.3389/fonc.2022.818953. eCollection 2022.

Authors

Xi Cao¹, Xian-Shu Gao¹, Wei Li², Peilin Liu¹, Shang-Bin Qin¹, Yan-Bin Dou¹, Hong-Zhen Li¹, Shiyu Shang³, Xiao-Bin Gu⁴, Ming-Wei Ma¹, Xin Qi¹, Mu Xie¹, Dian Wang⁵

Affiliations

¹ Department of Radiation Oncology, Peking University First Hospital, Beijing, China.
² Department of Radiology, Peking University First Hospital, Beijing, China.
³ Department of Oncology, Hebei North University, Zhangjiakou, Hebei, China.
⁴ Department of Radiation Oncology, First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
⁵ Department of Radiation Oncology, Rush University Medical Center, Chicago, IL, United States.

Abstract

Purpose: It is difficult to contour nerve structures with the naked eye due to poor differentiation between the nerve structures with other soft tissues on CT images. Magnetic resonance neurography (MRN) has the advantage in nerve visualization. The purpose of this study is to identify one MRN sequence to better assist the delineation of the lumbosacral plexus (LSP) nerves to assess the radiation dose to the LSP using the magnetic resonance (MR)/CT deformable coregistration technique.

Methods: A total of 18 cases of patients with prostate cancer and one volunteer with radiation-induced lumbosacral plexopathy (RILSP) were enrolled. The data of simulation CT images and original treatment plans were collected. Two MRN sequences (Lr_NerveVIEW sequence and Cs_NerveVIEW sequence) were optimized from a published MRN sequence (3D NerveVIEW sequence). The nerve visualization ability of the Lr_NerveVIEW sequence and the Cs_NerveVIEW sequence was evaluated via a four-point nerve visualization score (NVS) scale in the first 10 patients enrolled to determine the better MRN sequence for assisting nerve contouring. Deformable registration was applied to the selected MRN sequence and simulation CT images to get fused MR/CT images, on which the LSP was delineated. The contouring of the LSP did not alter treatment planning. The dosimetric data of the LSP nerve were collected from the dose-volume histogram in the original treatment plans. The data of the maximal dose (D_max) and the location of the maximal radiation point received by the LSP structures were collected.

Results: The Cs_NerveVIEW sequence gained lower NVS scores than the Lr_NerveVIEW sequence (Z=-2.887, p=0.004). The LSP structures were successfully created in 18 patients and one volunteer with MRN (Lr_NerveVIEW)/CT deformable registration techniques, and the LSP structures conformed with the anatomic distribution. In the patient cohort, the percentage of the LSP receiving doses exceeding 50, 55, and 60 Gy was 68% (12/18), 33% (6/18), and 17% (3/18), respectively. For the volunteer with RILSP, the maximum irradiation dose to his LSP nerves was 69 Gy.

Conclusion: The Lr_NerveVIEW MRN sequence performed better than the Cs_NerveVIEW sequence in nerve visualization. The dose in the LSP needs to be measured to understand the potential impact on treatment-induced neuropathy.

Keywords: MR neurography; contouring; lumbosacral plexus; multi-modality registration; radiation-induced plexopathy.