[Research progress of biomarkers in steroid-resistant nephrotic syndrome in children]

Y L Zhu; W Li; B B Yang; A Dong; F Wu; A M Liu; J H Mao

doi:10.3760/cma.j.cn112140-20220702-00610

[Research progress of biomarkers in steroid-resistant nephrotic syndrome in children]

Zhonghua Er Ke Za Zhi. 2022 Dec 2;60(12):1354-1357. doi: 10.3760/cma.j.cn112140-20220702-00610.

[Article in Chinese]

Authors

Y L Zhu¹, W Li², B B Yang³, A Dong⁴, F Wu¹, A M Liu⁵, J H Mao⁵

Affiliations

¹ Department of Traditional Chinese Medicine, the Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou 310052, China.
² Department of Clinical Laboratory, the Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou 310052, China.
³ Department of General Surgery, the Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou 310052, China.
⁴ Division of Hematology and Oncology, the Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou 310052, China.
⁵ Department of Nephrology, the Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou 310052, China.

PMID: 36444447
DOI: 10.3760/cma.j.cn112140-20220702-00610

Abstract

儿童激素耐药型肾病综合征（SRNS）是临床难题，预后较差，易进展为终末期肾病。判断SRNS病理类型及进展主要靠肾活检，然而其创伤性大、不易动态监测。寻找理想的、无创的、易获得的SRNS生物标志物，对早期发现、精准诊断、有效干预、改善预后至关重要。本文回顾儿童SRNS经典生物标志物，从SRNS发病机制着手，探索和识别免疫学、遗传学、转录组学及影像学潜在生物标志物，并对其未来走向进行展望。.

MeSH terms

Biomarkers
Child
Humans
Nephrotic Syndrome* / diagnosis
Steroids / therapeutic use

Substances

Biomarkers
Steroids