Mitochondria: how eminent in ageing and neurodegenerative disorders?

Hum Cell. 2023 Jan;36(1):41-61. doi: 10.1007/s13577-022-00833-y. Epub 2022 Nov 29.

Abstract

Numerous factors are implicated in the onset and progression of ageing and neurodegenerative disorders, with defects in cell energy supply and free radicals regulation designated as being the main functions of mitochondria and highly accentuated in plentiful studies. Hence, analysing the role of mitochondria as one of the main factors implicated in these disorders could undoubtedly come in handy with respect to disease prevention and treatment. In this review, first, we will explore how mitochondria account for neurodegenerative disorders and ageing and later will draw the various pathways contributing to mitochondrial dysfunction in their distinct way. Also, we will discuss the deviation-countering mechanisms, particularly mitophagy, a subset of autophagy known as a much larger cellular defence mechanism and regulatory system, along with its potential therapeutic effects. Last but not least, we will be highlighting the mitochondrial transfer experiments with animal models of neurodegenerative disorders.

Keywords: Ageing; Free radicals; Mitochondria; Mitochondrial transfer; Mitophagy; Neurodegenerative disorders.

Publication types

  • Review

MeSH terms

  • Aging / genetics
  • Animals
  • Autophagy / genetics
  • Mitochondria* / metabolism
  • Mitophagy / physiology
  • Neurodegenerative Diseases* / genetics
  • Neurodegenerative Diseases* / therapy