Comparative Efficacy of Platelet-Rich Plasma and Dry Needling for Management of Trigger Points in Masseter Muscle in Myofascial Pain Syndrome Patients: A Randomized Controlled Trial

J Oral Facial Pain Headache. 2022 Summer;36(3-4):253–262. doi: 10.11607/ofph.3188. Epub 2022 Nov 28.


Aims: To compare the efficacy of platelet-rich plasma (PRP) injection vs dry needling (DN) for management of trigger points in the masseter muscle in myofascial pain syndrome (MPS) patients.

Methods: This randomized controlled trial included 30 clinically confirmed cases of myofascial trigger points (MTrPs) in the masseter muscle who were randomly and equally (1:1) assigned to the test (PRP) and control (DN) groups. Both groups were evaluated for pain (visual analog scale [VAS]), range of functional movements, need for pain medication, patient satisfaction (Likert scale), and sleep (VAS) at baseline and 2-week, 1-month, and 3-month follow-ups. VAS pain and Likert score were also obtained at 6-month intervals.

Results: The use of PRP solution in MTrPs in MPS patients had a better effect on pain and patient satisfaction compared to DN.

Conclusion: PRP appears to be a more effective treatment modality compared to DN in the management of MTrPs in MPS patients.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Humans
  • Masseter Muscle
  • Myofascial Pain Syndromes* / therapy
  • Pain
  • Platelet-Rich Plasma*
  • Trigger Points