Potentially inappropriate medications based on TIME criteria and risk of in-hospital mortality in COVID-19 patients

Rev Assoc Med Bras (1992). 2022 Nov 28;68(12):1730-1736. doi: 10.1590/1806-9282.20220907. eCollection 2022.


Objective: This study aimed to evaluate the relationship between hospital admission potentially inappropriate medications use (PIM) and in-hospital mortality of COVID-19, considering other possible factors related to mortality.

Methods: The Turkish inappropriate medication use in the elderly (TIME) criteria were used to define PIM. The primary outcome of this study was in-hospital mortality.

Results: We included 201 older adults (mean age 73.1±9.4, 48.9% females). The in-hospital mortality rate and prevalence of PIM were 18.9% (n=38) and 96% (n=193), respectively. The most common PIM according to TIME to START was insufficient vitamin D and/or calcium intake per day. Proton-pump inhibitor use for multiple drug indications was the most prevalent PIM based on TIME to STOP findings. Mortality was related to PIM in univariate analysis (p=0.005) but not in multivariate analysis (p=0.599). Older age (hazards ratio (HR): 1.08; 95% confidence interval (CI): 1.02-1.13; p=0.005) and higher Nutritional Risk Screening 2002 (NRS-2002) scores were correlated with in-hospital mortality (HR: 1.29; 95%CI 1.00-1.65; p=0.042).

Conclusion: Mortality was not associated with PIM. Older age and malnutrition were related to in-hospital mortality in COVID-19.

MeSH terms

  • Aged
  • COVID-19*
  • Female
  • Hospital Mortality
  • Hospitalization
  • Humans
  • Inappropriate Prescribing
  • Male
  • Potentially Inappropriate Medication List*