Somatic TP53 mutations are pre-leukemic events in acute lymphoblastic leukemia

Blood. 2022 Nov 30;blood.2022017249. doi: 10.1182/blood.2022017249. Online ahead of print.

Guranda Chitadze^{1

2

3}, Anna Stengel⁴, Cathrin John-Klaua¹, Julien Bruckmüller^{1

5}, Heiko Trautmann^{1

2}, Michaela Kotrova^{1

2}, Franziska Darzentas^{1

2}, Miriam Kelm^{1

2}, Karol Pal^{1

6}, Nikos Darzentas^{1

2}, Lorenz Bastian^{1

2

3}, Britta Kehden^{1

2}, Wiebke Wessels^{1

2}, Aeint-Steffen Ströh^{1

2}, Hans-Heinrich Oberg⁷, Philipp M Altrock⁸, Constance Baer⁴, Manja Meggendorfer⁴, Nicola Goekbuget⁹, Claudia D Baldus^{1

2

3}, Claudia Haferlach⁴, Monika Brüggemann^{1

2

3}

¹ 2nd Internal Medicine Department, Hematology Lab Kiel, Christian-Albrechts University of Kiel and University Hospital Schleswig-Holstein (UKSH), Kiel, Germany
² University Cancer Center Schleswig-Holstein (UCCSH), University Hospital Schleswig-Holstein, Kiel, Germany
³ Clinical Research Unit "CATCH-ALL" (KFO 5010/1), funded by the Deutsche Forschungsgemeinschaft (DFG, German Research Foundation), Germany
⁴ Munich Leukemia Laboratory, Munich, Germany
⁵ Solana Research GmbH, Windeby, Germany
⁶ CEITEC-Central European Institute of Technology, Masaryk University, Brno, Czech Republic
⁷ Institute of Immunology, Christian-Albrechts University of Kiel and University Hospital Schleswig-Holstein (UKSH), Kiel, Germany
⁸ Department of Evolutionary Theory, Max Planck Institute for Evolutionary Biology, Ploen, Germany
⁹ Department of Medicine II, Goethe University Hospital, Frankfurt, Germany

No abstract available