Antiproliferative effects and main molecular mechanisms of Brazilian native fruits and their by-products on lung cancer

Ana Paula da Fonseca Machado; Mariana da Rocha Alves; Roberto de Paula do Nascimento; Lívia Mateus Reguengo; Mario Roberto Marostica Junior

doi:10.1016/j.foodres.2022.111953

Antiproliferative effects and main molecular mechanisms of Brazilian native fruits and their by-products on lung cancer

Food Res Int. 2022 Dec;162(Pt A):111953. doi: 10.1016/j.foodres.2022.111953. Epub 2022 Sep 22.

Authors

Ana Paula da Fonseca Machado¹, Mariana da Rocha Alves², Roberto de Paula do Nascimento³, Lívia Mateus Reguengo⁴, Mario Roberto Marostica Junior⁵

Affiliations

¹ University of Campinas, School of Food Engineering, Monteiro Lobato Street 80, 13083-862 Campinas, São Paulo State, Brazil. Electronic address: anapfmachado@hotmail.com.
² University of Campinas, School of Food Engineering, Monteiro Lobato Street 80, 13083-862 Campinas, São Paulo State, Brazil. Electronic address: mariana.roalves@gmail.com.
³ University of Campinas, School of Food Engineering, Monteiro Lobato Street 80, 13083-862 Campinas, São Paulo State, Brazil. Electronic address: roberto_beto1@hotmail.com.
⁴ University of Campinas, School of Food Engineering, Monteiro Lobato Street 80, 13083-862 Campinas, São Paulo State, Brazil. Electronic address: liviareguengo@gmail.com.
⁵ University of Campinas, School of Food Engineering, Monteiro Lobato Street 80, 13083-862 Campinas, São Paulo State, Brazil. Electronic address: mmarosti@unicamp.br.

PMID: 36461205
DOI: 10.1016/j.foodres.2022.111953

Abstract

Lung Cancer (LC) is an emergent disease widespread globally. Compared to other types of cancer, LC has one of the lowest survival rates (18%). As some risk factors associated with the development of lung carcinogenesis are still unavoidable, researchers have been trying to find efficient and safe alternatives that can help prevent LC or even attenuate its rapid evolution after diagnosis. Studies with natural products promise to offer biological effects against several types of cancers, including LC. The uncountable types of plant matrices dispersed in nature, or even their extracts, contain a powerful composition of bioactive compounds with promising biological effects on LC. The biomes in Brazil are examples of regions with a great biodiversity of bioactive compounds-rich fruits. Therefore, this review aimed to present the potential anticancer effect of Brazilian native fruits, their fractions, and by-products on LC through the elucidation of the main molecular mechanisms involved. The Brazilian plant matrices discussed here (açaí, achiote, araticum, camu camu, cocoa, jaboticaba, genipap, guarana, and pequi) showed promising evidence by inducing cellular apoptosis, reducing cancer cell viability and tumor growth, and regulating cell cycle.

Keywords: Antitumor; Bioactive compound; Carcinogenesis; Functional food; Molecular mechanisms; Signaling pathways.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Brazil
Carcinogenesis
Fruit
Lung Neoplasms*
Myrtaceae*