Challenges in osteoarthritis treatment

Tissue Cell. 2023 Feb:80:101992. doi: 10.1016/j.tice.2022.101992. Epub 2022 Nov 28.


Osteoarthritis (OA) is the most common form of arthritis and a degenerative joint cartilage disease that is the most common cause of disability in the world among the elderly. It leads to social, psychological, and economic costs with financial consequences. The principles of OA treatment are to reduce pain and stiffness as well as maintain function. In recent years, due to a better understanding of the underlying pathophysiology of OA, a number of potential therapeutic advances have been made, which include tissue engineering, immune system manipulation, surgical technique, pharmacological, and non-pharmacological treatments. Despite this, there is still no certain cure for OA, and different OA treatments are usually considered in relation to the stage of the disease. The purpose of the present review is to summarize and discuss the latest results of new treatments for OA and potential targets for future research.

Keywords: Cartilage gene therapy; Cartilage tissue engineering; Exosomes; Joint anatomy; Osteoarthritis; Surgical techniques.

Publication types

  • Review

MeSH terms

  • Aged
  • Humans
  • Osteoarthritis* / therapy
  • Tissue Engineering