Functional properties of circular RNAs and research progress in gastric cancer

Ping'an Ding; Pengpeng Liu; Haotian Wu; Peigang Yang; Yuan Tian; Qun Zhao

doi:10.3389/fonc.2022.954637

Functional properties of circular RNAs and research progress in gastric cancer

Front Oncol. 2022 Nov 16:12:954637. doi: 10.3389/fonc.2022.954637. eCollection 2022.

Authors

Ping'an Ding^{1

2}, Pengpeng Liu^{1

2}, Haotian Wu^{1

2}, Peigang Yang^{1

2}, Yuan Tian^{1

2}, Qun Zhao^{1

2}

Affiliations

¹ The Third Department of Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
² Hebei Key Laboratory of Precision Diagnosis and Comprehensive Treatment of Gastric Cancer, Shijiazhuang, China.

Abstract

Circular RNAs (circRNAs) are a class of closed circular non-coding RNAs widely exist in eukaryotes, with high stability and species conservation. A large number of studies have shown that circRNAs are abnormally expressed in various tumor tissues, and are abundant in plasma with long half-life and high specificity, which may be served as potential tumor biomarkers for early diagnosis, treatment and prognosis of malignant tumors. However, the role of circRNAs is still poorly understood in gastric cancer. This article reviews the research progress of circRNAs in gastric cancer in recent years so as to explore the relationship between circRNAs and the occurrence and the development of gastric cancer, and provide new ideas for the diagnosis and treatment of gastric cancer.

Keywords: Circular RNA; gastric cancer; marker; molecular mechanisms; therapeutic target.

Publication types

Review