Gold nanoparticle decoration potentiate the antibacterial enhancement of TiO2 nanotubes via sonodynamic therapy against peri-implant infections

Yue Sun; Wenzhou Xu; Cong Jiang; Tianyu Zhou; Qiqi Wang; Lan A

doi:10.3389/fbioe.2022.1074083

Gold nanoparticle decoration potentiate the antibacterial enhancement of TiO₂ nanotubes via sonodynamic therapy against peri-implant infections

Front Bioeng Biotechnol. 2022 Nov 17:10:1074083. doi: 10.3389/fbioe.2022.1074083. eCollection 2022.

Authors

Yue Sun^{1

2}, Wenzhou Xu³, Cong Jiang¹, Tianyu Zhou¹, Qiqi Wang³, Lan A^{1

2}

Affiliations

¹ Department of Oral Implantology, School and Hospital of Stomatology, Jilin University, Changchun, China.
² Jilin Provincial Key Laboratory of Sciences and Technology for Stomatology Nanoengineering, Changchun, China.
³ Department of Periodontology, School and Hospital of Stomatology, Jilin University, Changchun, China.

Abstract

Inflammatory damage from bacterial biofilms usually causes the failure of tooth implantation. A promising solution for this challenge is to use an implant surface with a long-term, in-depth and efficient antibacterial feature. In this study, we developed an ultrasound-enhanced antibacterial implant surface based on Au nanoparticle modified TiO₂ nanotubes (AuNPs-TNTs). As an artificial tooth surface, films based on AuNPs-TNTs showed excellent biocompatibility. Importantly, compared to bare titania surface, a larger amount of reactive oxygen radicals was generated on AuNPs-TNTs under an ultrasound treatment. For a proof-of-concept application, Porphyromonas gingivalis (P. gingivalis) was used as the model bacteria; the as-proposed AuNPs-TNTs exhibited significantly enhanced antibacterial activity under a simple ultrasound treatment. This antibacterial film offers a new way to design the surface of an artificial implant coating for resolving the bacterial infection induced failure of dental implants.

Keywords: ROS; antibacterial; dental implant; sonodynamic therapy; titania nanotube.